Anabolic Agents For Muscle Loss

The course of many chronic illnesses such as obstructive pulmonary disease, end stage renal disease, congestive heart failure and some cancers is punctuated by loss of muscle mass. This loss of muscle mass is a major contributor to functional limitation, symptom severity and disability. Candidate function promoting anabolic agents are in development to stimulate bone and muscle growth and reverse the progression of muscle wasting. sarms are currently the most advanced in this category of drugs and have demonstrated tissue selective effects including the ability to stimulate muscle growth, reduce prostate size, inhibit breast cancer cell growth and shrink the uterus.This link

SARMs have shown promising preclinical proof of concept and toxicology studies, and several compounds are in phase I and II clinical trials (1, 2). The majority of these SARMs (i.e., andarine, ostarine, enobosarm, and ligandrol) have been studied for their potential to improve skeletal muscle mass in healthy populations and increase strength. In addition, several other potential therapeutic applications for SARMs are being explored such as the treatment of sarcopenia, osteoporosis, aging-related depressive symptoms, and benign prostatic hyperplasia (BPH) (2, 3).

SARMs for Women: A Closer Look at Selective Androgen Receptor Modulators for Females

However, safety data from human studies is limited. There are case reports of drug-induced liver injury (DILI), elevated alanine aminotransferase, Achilles tendon rupture and rhabdomyolysis. Furthermore, illegal SARMs sold on Internet-based gray markets may be contaminated with other substances such as steroids, posing significant health risks for users who take these drugs. In a recent study, 70% of SARMs purchased online did not contain the substance or dosage listed on their label (3, 4). Despite these issues, the results from the recently completed POWER trials showed that enobosarm (GTx-024) significantly increased lean body mass and improved handgrip strength in patients with cancer cachexia, although improvements in physical function were not as pronounced.

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